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Structure Therapeutics Inc. (GPCR)

Historical prices through 2026-10-08Latest fiscal period 2025-12-31

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Structure Therapeutics Inc. (GPCR) · Nasdaq · USD · Sector unavailable · CIK 0001888886

Annual coverage: 2022-12-31–2025-12-31 (4 periods). Financial snapshot built 2026-10-09.

GPCR annual financial history

All stored annual observations, independent of the chart window. Per-share amounts in USD. Unavailable values are not zero.

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Annual EPS, cash flow, dividends, and fiscal-year dividend yield for Structure Therapeutics Inc.
Fiscal year / end	Basic EPS	Diluted EPS	FCF / share	Dividends / share	Fiscal-year dividend yield	Filing sources
2025 2025-12-31	-0.80	-0.80	-1.27	Unavailable	Unavailable	Basic EPS (2026-02-26) Diluted EPS (2026-02-26) Operating cash flow (2026-02-26) · Capex (2026-02-26)
2024 2024-12-31	-0.78	-0.78	-0.75	Unavailable	Unavailable	Basic EPS (2026-02-26) Diluted EPS (2026-02-26) Operating cash flow (2026-02-26) · Capex (2026-02-26)
2023 2023-12-31	-0.81	-0.81	-0.74	Unavailable	Unavailable	Basic EPS (2026-02-26) Diluted EPS (2026-02-26) Operating cash flow (2026-02-26) · Capex (2026-02-26)
2022 2022-12-31	-5.51	-5.51	-4.83	Unavailable	Unavailable	Basic EPS (2024-03-08) Diluted EPS (2024-03-08) Operating cash flow (2024-03-08) · Capex (2024-03-08)

Annual per-share context (USD/share)

Complete annual history, independent of chart loading and range. Revenue/share is annual revenue per average diluted share. Debt/share is borrowings per year-end common share, excluding leases. Missing inputs remain unavailable. Metric definitions.

Fiscal end	Revenue / share	Total debt / share	Inputs & filing sources
2025-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: 177596000; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 212513000 averageDilutedShares (2026-02-26) periodEndShares (2026-02-26)
2024-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: 157922000; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 171860000 averageDilutedShares (2026-02-26) periodEndShares (2026-02-26)
2023-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: 110198000; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 139220000 averageDilutedShares (2026-02-26) periodEndShares (2025-02-27)
2022-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: 9584000; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 10527000 averageDilutedShares (2024-03-08) periodEndShares (2024-03-08)

Annual returns and cash generation (%)

Complete annual history, independent of chart loading and range. FCF margin and FCF / net income use matching annual totals. ROCE uses positive exact opening and closing capital-employed bases. Inputs, scopes and unavailable reasons are disclosed below. Missing inputs remain unavailable. Metric definitions.

Fiscal end	FCF margin (%)	FCF / net income (%)	ROCE (%)	Inputs & filing sources
2025-12-31	Unavailable	Unavailable	-14.79	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-225813000,"capex":{"accession":"0001104659-26-020562","end":"2025-12-31","filed":"2026-02-26","form":"10-K","start":"2025-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001104659-26-020562","end":"2025-12-31","filed":"2026-02-26","form":"10-K","start":"2025-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-141202000,"tag":"ProfitLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"operatingIncome":{"value":-176560000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingAssets":{"value":903330000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingCurrentLiabilities":{"value":36021000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingCapitalEmployed":{"value":867309000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":864843000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingTotalEquity":{"value":864843000,"inputNames":["openingParentEquity","openingAssets","openingLiabilities"]},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":38487000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingCash":{"value":169510000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -14.787628845256712 fcfMargin component 1 (2026-02-26) · fcfMargin component 2 (2026-02-26) cashConversion component 1 (2026-02-26) · cashConversion component 2 (2026-02-26) · cashConversion component 3 (2026-02-26) roce component 1 (2026-02-26) · roce component 2 (2026-02-26) · roce component 3 (2026-02-26) · roce component 4 (2026-02-26) · roce component 5 (2026-02-26)
2024-12-31	Unavailable	Unavailable	-23.89	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-117926000,"capex":{"accession":"0001104659-26-020562","end":"2024-12-31","filed":"2026-02-26","form":"10-K","start":"2024-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001104659-26-020562","end":"2024-12-31","filed":"2026-02-26","form":"10-K","start":"2024-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-122526000,"tag":"ProfitLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"operatingIncome":{"value":-158228000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingAssets":{"value":482017000,"tag":"Assets","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-02-27","accession":"0001558370-25-001826","form":"10-K"},"openingCurrentLiabilities":{"value":24740000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-02-27","accession":"0001558370-25-001826","form":"10-K"},"openingCapitalEmployed":{"value":457277000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":452966000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2023-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":29051000,"tag":"Liabilities","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-02-27","accession":"0001558370-25-001826","form":"10-K"},"openingCash":{"value":129792000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-02-27","accession":"0001558370-25-001826","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2023-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":903330000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"closingCurrentLiabilities":{"value":36021000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"closingCapitalEmployed":{"value":867309000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":864843000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"closingTotalEquity":{"value":864843000,"inputNames":["closingParentEquity","closingAssets","closingLiabilities"]},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":38487000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"closingCash":{"value":169510000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-122526000,"tag":"NetIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":310000,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"pretaxIncome":{"value":-122216000,"tag":"IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Positive pretax income required"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Positive pretax income required"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":662293000,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -23.890936488835003 fcfMargin component 1 (2026-02-26) · fcfMargin component 2 (2026-02-26) cashConversion component 1 (2026-02-26) · cashConversion component 2 (2026-02-26) · cashConversion component 3 (2026-02-26) roce component 1 (2026-02-26) · roce component 2 (2025-02-27) · roce component 3 (2025-02-27) · roce component 4 (2026-02-26) · roce component 5 (2026-02-26)
2023-12-31	Unavailable	Unavailable	-37.92	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-81655000,"capex":{"accession":"0001104659-26-020562","end":"2023-12-31","filed":"2026-02-26","form":"10-K","start":"2023-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001104659-26-020562","end":"2023-12-31","filed":"2026-02-26","form":"10-K","start":"2023-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-89620000,"tag":"ProfitLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"operatingIncome":{"value":-102775000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingAssets":{"value":97845000,"tag":"Assets","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"openingCurrentLiabilities":{"value":13010000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"openingCapitalEmployed":{"value":84835000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":-115140000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2022-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":13010000,"tag":"Liabilities","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"openingCash":{"value":26091000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2023-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":-89620000,"tag":"NetIncomeLossAvailableToCommonStockholdersBasic","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"incomeTaxExpense":{"value":236000,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"pretaxIncome":{"value":-89384000,"tag":"IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Positive pretax income required"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Positive pretax income required"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":271056000,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -37.916519095685025 fcfMargin component 1 (2026-02-26) · fcfMargin component 2 (2026-02-26) cashConversion component 1 (2026-02-26) · cashConversion component 2 (2026-02-26) · cashConversion component 3 (2026-02-26) roce component 1 (2026-02-26) · roce component 2 (2024-03-08) · roce component 3 (2024-03-08) · roce component 4 (2025-02-27) · roce component 5 (2025-02-27)
2022-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-46275000,"capex":{"accession":"0001558370-24-002791","end":"2022-12-31","filed":"2024-03-08","form":"10-K","start":"2022-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001558370-24-002791","end":"2022-12-31","filed":"2024-03-08","form":"10-K","start":"2022-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-51321000,"tag":"ProfitLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"operatingIncome":{"value":-52561000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"openingAssets":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCurrentLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCapitalEmployed":{"value":null,"inputNames":["openingAssets","openingCurrentLiabilities"],"reason":"Exact assets/current-liabilities balance missing, conflicting or from different filings at 2021-12-31"},"openingParentEquity":{"value":-64735000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2021-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCash":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2021-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":97845000,"tag":"Assets","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"closingCurrentLiabilities":{"value":13010000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"closingCapitalEmployed":{"value":84835000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":-115140000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2022-12-31","filed":"2026-02-26","accession":"0001104659-26-020562","form":"10-K"},"closingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":13010000,"tag":"Liabilities","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"closingCash":{"value":26091000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2022-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":-52836000,"tag":"NetIncomeLossAvailableToCommonStockholdersBasic","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"incomeTaxExpense":{"value":17000,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"pretaxIncome":{"value":-51304000,"tag":"IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-08","accession":"0001558370-24-002791","form":"10-K"},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Positive pretax income required"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Positive pretax income required"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":null,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: matching numerator and positive exact opening/closing CapitalEmployed required; ambiguous scopes remain unavailable; unavailable: openingCapitalEmployed; Exact assets/current-liabilities balance missing, conflicting or from different filings at 2021-12-31 fcfMargin component 1 (2024-03-08) · fcfMargin component 2 (2024-03-08) cashConversion component 1 (2024-03-08) · cashConversion component 2 (2024-03-08) · cashConversion component 3 (2024-03-08) roce component 1 (2024-03-08) · roce component 2 (2024-03-08) · roce component 3 (2024-03-08)

Annual operating facts

Complete annual history, independent of chart loading and range. Operating margin is operating profit as a percentage of revenue; net margin is consolidated net profit as a percentage of revenue. Negative margins show losses. Missing inputs remain unavailable. Metric definitions.

Fiscal end	Revenue (USD)	Operating margin (%)	Net margin (%)	Inputs & filing sources
2025-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -176560000; netIncome: -141202000 operatingIncome (2026-02-26) netIncome (2026-02-26)
2024-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -158228000; netIncome: -122526000 operatingIncome (2026-02-26) netIncome (2026-02-26)
2023-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -102775000; netIncome: -89620000 operatingIncome (2026-02-26) netIncome (2026-02-26)
2022-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -52561000; netIncome: -51321000 operatingIncome (2024-03-08) netIncome (2024-03-08)

Structure Therapeutics Inc. (GPCR) P/E ratio history

The interactive P/E chart contains all 193 stored weekly price points (2023-02-03–2026-10-08); 0 have an eligible basic or diluted ratio. Annual EPS is carried forward from its fiscal end. Use the P/E range bar or any other chart range bar to change all five chart windows.

Fiscal-year-end snapshots

No positive annual EPS with an eligible fiscal-year-end price is available in this snapshot.

Annual P/E = eligible fiscal-year-end close ÷ reported annual EPS. This is retrospective annual P/E, not TTM or forward P/E. Why we use annual data. Missing or non-positive EPS and missing eligible prices produce unavailable ratios.

Explore the P/E chart and optional reference lines · How P/E history is calculated.

Complete annual P/E history (4 fiscal periods)

Full stored fiscal-year-end P/E history, independent of the selected chart window. Ratios in ×; prices in USD.
Fiscal end	Price date	Close	Price basis	Basic P/E	Diluted P/E	EPS filings
2025-12-31	2025-12-26	68.34	Adjusted close	Unavailable	Unavailable	Basic EPS (2026-02-26) Diluted EPS (2026-02-26)
2024-12-31	2024-12-27	29.04	Adjusted close	Unavailable	Unavailable	Basic EPS (2026-02-26) Diluted EPS (2026-02-26)
2023-12-31	2023-12-29	40.76	Adjusted close	Unavailable	Unavailable	Basic EPS (2026-02-26) Diluted EPS (2026-02-26)
2022-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Basic EPS (2024-03-08) Diluted EPS (2024-03-08)

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