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Milestone Pharmaceuticals Inc. (MIST)

Historical prices through 2026-10-08Latest fiscal period 2025-12-31

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Price date	EPS fiscal end	Basic P/E (×)	Diluted P/E (×)	P/S (×)	P/FCF (×)

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Formula: min(60, 15 × ((1 + CAGR / 100) / 1.10)^{years × 0.6})

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Annual data and sources

Milestone Pharmaceuticals Inc. (MIST) · Nasdaq · USD · Sector unavailable · CIK 0001408443

Annual coverage: 2018-12-31–2025-12-31 (8 periods). Financial snapshot built 2026-10-09.

MIST annual financial history

All stored annual observations, independent of the chart window. Per-share amounts in USD. Unavailable values are not zero.

See the calculation and limitations.

Annual EPS, cash flow, dividends, and fiscal-year dividend yield for Milestone Pharmaceuticals Inc.
Fiscal year / end	Basic EPS	Diluted EPS	FCF / share	Dividends / share	Fiscal-year dividend yield	Filing sources
2025 2025-12-31	-0.75	-0.75	Unavailable	Unavailable	Unavailable	Basic EPS (2026-03-20) Diluted EPS (2026-03-20) Operating cash flow (2026-03-20) · Capex (2026-03-20)
2024 2024-12-31	-0.67	-0.67	Unavailable	Unavailable	Unavailable	Basic EPS (2026-03-20) Diluted EPS (2026-03-20) Operating cash flow (2026-03-20) · Capex (2026-03-20)
2023 2023-12-31	-1.39	-1.39	Unavailable	Unavailable	Unavailable	Basic EPS (2025-03-13) Diluted EPS (2025-03-13) Operating cash flow (2025-03-13) · Capex (2025-03-13)
2022 2022-12-31	-1.38	-1.38	Unavailable	Unavailable	Unavailable	Basic EPS (2024-03-21) Diluted EPS (2024-03-21) Operating cash flow (2024-03-21) · Capex (2024-03-21)
2021 2021-12-31	-1.02	-1.02	Unavailable	Unavailable	Unavailable	Basic EPS (2023-03-29) Diluted EPS (2022-03-24)
2020 2020-12-31	-1.70	-1.70	Unavailable	Unavailable	Unavailable	Basic EPS (2022-03-24) Diluted EPS (2022-03-24)
2019 2019-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Operating cash flow (2021-03-29) · Capex (2021-03-29)
2018 2018-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Operating cash flow (2020-10-23) · Capex (2020-10-23)

Annual per-share context (USD/share)

Complete annual history, independent of chart loading and range. Revenue/share is annual revenue per average diluted share. Debt/share is borrowings per year-end common share, excluding leases. Missing inputs remain unavailable. Metric definitions.

Fiscal end	Revenue / share	Total debt / share	Inputs & filing sources
2025-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 106236344 periodEndShares (2026-03-20)
2024-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 53353984 periodEndShares (2026-03-20)
2023-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 33483111 periodEndShares (2025-03-13)
2022-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 34286002 periodEndShares (2024-03-21)
2021-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 29897559 periodEndShares (2023-03-29)
2020-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 29827997 periodEndShares (2022-03-24)
2019-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 24505748 periodEndShares (2021-03-29)
2018-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 596787 periodEndShares (2020-10-23)

Annual returns and cash generation (%)

Complete annual history, independent of chart loading and range. FCF margin and FCF / net income use matching annual totals. ROCE uses positive exact opening and closing capital-employed bases. Inputs, scopes and unavailable reasons are disclosed below. Missing inputs remain unavailable. Metric definitions.

Fiscal end	FCF margin (%)	FCF / net income (%)	ROCE (%)	Inputs & filing sources
2025-12-31	Unavailable	Unavailable	-74.44	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-49343000,"capex":{"accession":"0001104659-26-032415","end":"2025-12-31","filed":"2026-03-20","form":"10-K","start":"2025-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001104659-26-032415","end":"2025-12-31","filed":"2026-03-20","form":"10-K","start":"2025-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-63058000,"tag":"ProfitLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"operatingIncome":{"value":-62140000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"openingAssets":{"value":75499000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"openingCurrentLiabilities":{"value":8126000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"openingCapitalEmployed":{"value":67373000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":13147000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"openingTotalEquity":{"value":13147000,"inputNames":["openingParentEquity","openingAssets","openingLiabilities"]},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":62352000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"openingCash":{"value":25314000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":113561000,"tag":"Assets","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingCurrentLiabilities":{"value":13979000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingCapitalEmployed":{"value":99582000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":41769000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingTotalEquity":{"value":41769000,"inputNames":["closingParentEquity","closingAssets","closingLiabilities"]},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":71792000,"tag":"Liabilities","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingCash":{"value":73046000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2025-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-63058000,"tag":"NetIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"pretaxIncome":{"value":-63058000,"tag":"IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":83477500,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -74.43922014914199 fcfMargin component 1 (2026-03-20) · fcfMargin component 2 (2026-03-20) cashConversion component 1 (2026-03-20) · cashConversion component 2 (2026-03-20) · cashConversion component 3 (2026-03-20) roce component 1 (2026-03-20) · roce component 2 (2026-03-20) · roce component 3 (2026-03-20) · roce component 4 (2026-03-20) · roce component 5 (2026-03-20)
2024-12-31	Unavailable	Unavailable	-62.20	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-28881000,"capex":{"accession":"0001104659-26-032415","end":"2024-12-31","filed":"2026-03-20","form":"10-K","start":"2024-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001104659-26-032415","end":"2024-12-31","filed":"2026-03-20","form":"10-K","start":"2024-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-41519000,"tag":"ProfitLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"operatingIncome":{"value":-42102000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"openingAssets":{"value":75226000,"tag":"Assets","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-13","accession":"0001558370-25-002849","form":"10-K"},"openingCurrentLiabilities":{"value":7226000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-13","accession":"0001558370-25-002849","form":"10-K"},"openingCapitalEmployed":{"value":68000000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":16771000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2023-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":58455000,"tag":"Liabilities","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-13","accession":"0001558370-25-002849","form":"10-K"},"openingCash":{"value":13760000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-13","accession":"0001558370-25-002849","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2023-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":75499000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingCurrentLiabilities":{"value":8126000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingCapitalEmployed":{"value":67373000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":13147000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingTotalEquity":{"value":13147000,"inputNames":["closingParentEquity","closingAssets","closingLiabilities"]},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":62352000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingCash":{"value":25314000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-41519000,"tag":"NetIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"pretaxIncome":{"value":-41519000,"tag":"IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-20","accession":"0001104659-26-032415","form":"10-K"},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":67686500,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -62.20147296728299 fcfMargin component 1 (2026-03-20) · fcfMargin component 2 (2026-03-20) cashConversion component 1 (2026-03-20) · cashConversion component 2 (2026-03-20) · cashConversion component 3 (2026-03-20) roce component 1 (2026-03-20) · roce component 2 (2025-03-13) · roce component 3 (2025-03-13) · roce component 4 (2026-03-20) · roce component 5 (2026-03-20)
2023-12-31	Unavailable	Unavailable	-89.62	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-46536000,"capex":{"accession":"0001558370-25-002849","end":"2023-12-31","filed":"2025-03-13","form":"10-K","start":"2023-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001558370-25-002849","end":"2023-12-31","filed":"2025-03-13","form":"10-K","start":"2023-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-59685000,"tag":"ProfitLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-13","accession":"0001558370-25-002849","form":"10-K"},"operatingIncome":{"value":-61098000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-13","accession":"0001558370-25-002849","form":"10-K"},"openingAssets":{"value":74483000,"tag":"Assets","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-21","accession":"0001558370-24-003666","form":"10-K"},"openingCurrentLiabilities":{"value":6139000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-21","accession":"0001558370-24-003666","form":"10-K"},"openingCapitalEmployed":{"value":68344000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":66348000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2022-12-31","filed":"2025-03-13","accession":"0001558370-25-002849","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":8135000,"tag":"Liabilities","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-21","accession":"0001558370-24-003666","form":"10-K"},"openingCash":{"value":7636000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-21","accession":"0001558370-24-003666","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -89.62330575602887 fcfMargin component 1 (2025-03-13) · fcfMargin component 2 (2025-03-13) cashConversion component 1 (2025-03-13) · cashConversion component 2 (2025-03-13) · cashConversion component 3 (2025-03-13) roce component 1 (2025-03-13) · roce component 2 (2024-03-21) · roce component 3 (2024-03-21) · roce component 4 (2025-03-13) · roce component 5 (2025-03-13)
2022-12-31	Unavailable	Unavailable	-65.75	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-52741000,"capex":{"accession":"0001558370-24-003666","end":"2022-12-31","filed":"2024-03-21","form":"10-K","start":"2022-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001558370-24-003666","end":"2022-12-31","filed":"2024-03-21","form":"10-K","start":"2022-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-58388000,"tag":"ProfitLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-21","accession":"0001558370-24-003666","form":"10-K"},"operatingIncome":{"value":-59642000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-21","accession":"0001558370-24-003666","form":"10-K"},"openingAssets":{"value":119849000,"tag":"Assets","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-29","accession":"0001558370-23-004871","form":"10-K"},"openingCurrentLiabilities":{"value":6775000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-29","accession":"0001558370-23-004871","form":"10-K"},"openingCapitalEmployed":{"value":113074000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":112600000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2021-12-31","filed":"2024-03-21","accession":"0001558370-24-003666","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":7249000,"tag":"Liabilities","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-29","accession":"0001558370-23-004871","form":"10-K"},"openingCash":{"value":114141000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-29","accession":"0001558370-23-004871","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -65.7509177700118 fcfMargin component 1 (2024-03-21) · fcfMargin component 2 (2024-03-21) cashConversion component 1 (2024-03-21) · cashConversion component 2 (2024-03-21) · cashConversion component 3 (2024-03-21) roce component 1 (2024-03-21) · roce component 2 (2023-03-29) · roce component 3 (2023-03-29) · roce component 4 (2024-03-21) · roce component 5 (2024-03-21)
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fcfMargin: Stored FCF total has no matching annual OCF/capex duration; cashConversion: Stored FCF total has no matching annual OCF/capex duration; roce: -33.53432805608648 cashConversion component 1 (2023-03-29) roce component 1 (2023-03-29) · roce component 2 (2022-03-24) · roce component 3 (2022-03-24) · roce component 4 (2023-03-29) · roce component 5 (2023-03-29)
2020-12-31	Unavailable	Unavailable	-39.17	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-49967000,"tag":"ProfitLoss","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-24","accession":"0001558370-22-004205","form":"10-K"},"operatingIncome":{"value":-50710000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-24","accession":"0001558370-22-004205","form":"10-K"},"openingAssets":{"value":123428000,"tag":"Assets","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"openingCurrentLiabilities":{"value":8327000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"openingCapitalEmployed":{"value":115101000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":114917000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2019-12-31","filed":"2022-03-24","accession":"0001558370-22-004205","form":"10-K"},"openingTotalEquity":{"value":114917000,"tag":"StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest","unit":"USD","start":null,"end":"2019-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"openingCash":{"value":119818000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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fcfMargin: Stored FCF total has no matching annual OCF/capex duration; cashConversion: Stored FCF total has no matching annual OCF/capex duration; roce: -39.171005268117845 cashConversion component 1 (2022-03-24) roce component 1 (2022-03-24) · roce component 2 (2021-03-29) · roce component 3 (2021-03-29) · roce component 4 (2022-03-24) · roce component 5 (2022-03-24)
2019-12-31	Unavailable	Unavailable	-58.27	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-51565000,"capex":{"accession":"0001558370-21-003631","end":"2019-12-31","filed":"2021-03-29","form":"10-K","start":"2019-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001558370-21-003631","end":"2019-12-31","filed":"2021-03-29","form":"10-K","start":"2019-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-55229000,"tag":"ProfitLoss","unit":"USD","start":"2019-01-01","end":"2019-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"operatingIncome":{"value":-57881000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2019-01-01","end":"2019-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"openingAssets":{"value":88081000,"tag":"Assets","unit":"USD","start":null,"end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"openingCurrentLiabilities":{"value":4533000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"openingCapitalEmployed":{"value":83548000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":83548000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2018-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"openingTotalEquity":{"value":-55210000,"tag":"StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest","unit":"USD","start":null,"end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"openingCash":{"value":85947000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2019-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-55229000,"tag":"NetIncomeLoss","unit":"USD","start":"2019-01-01","end":"2019-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":-56000,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2019-01-01","end":"2019-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":99324500,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -58.27464522851864 fcfMargin component 1 (2021-03-29) · fcfMargin component 2 (2021-03-29) cashConversion component 1 (2021-03-29) · cashConversion component 2 (2021-03-29) · cashConversion component 3 (2021-03-29) roce component 1 (2021-03-29) · roce component 2 (2020-10-23) · roce component 3 (2020-10-23) · roce component 4 (2021-03-29) · roce component 5 (2021-03-29)
2018-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-21051000,"capex":{"accession":"0001104659-20-117701","end":"2018-12-31","filed":"2020-10-23","form":"10-K/A","start":"2018-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001104659-20-117701","end":"2018-12-31","filed":"2020-10-23","form":"10-K/A","start":"2018-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-23185000,"tag":"ProfitLoss","unit":"USD","start":"2018-01-01","end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"operatingIncome":{"value":-23822000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2018-01-01","end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"openingAssets":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCurrentLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCapitalEmployed":{"value":null,"inputNames":["openingAssets","openingCurrentLiabilities"],"reason":"Exact assets/current-liabilities balance missing, conflicting or from different filings at 2017-12-31"},"openingParentEquity":{"value":25985000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2017-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCash":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2017-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":88081000,"tag":"Assets","unit":"USD","start":null,"end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"closingCurrentLiabilities":{"value":4533000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"closingCapitalEmployed":{"value":83548000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":83548000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2018-12-31","filed":"2021-03-29","accession":"0001558370-21-003631","form":"10-K"},"closingTotalEquity":{"value":-55210000,"tag":"StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest","unit":"USD","start":null,"end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"closingCash":{"value":85947000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2018-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-23185000,"tag":"NetIncomeLoss","unit":"USD","start":"2018-01-01","end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":74000,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2018-01-01","end":"2018-12-31","filed":"2020-10-23","accession":"0001104659-20-117701","form":"10-K/A"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":null,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: matching numerator and positive exact opening/closing CapitalEmployed required; ambiguous scopes remain unavailable; unavailable: openingCapitalEmployed; Exact assets/current-liabilities balance missing, conflicting or from different filings at 2017-12-31 fcfMargin component 1 (2020-10-23) · fcfMargin component 2 (2020-10-23) cashConversion component 1 (2020-10-23) · cashConversion component 2 (2020-10-23) · cashConversion component 3 (2020-10-23) roce component 1 (2020-10-23) · roce component 2 (2020-10-23) · roce component 3 (2020-10-23)

Annual operating facts

Complete annual history, independent of chart loading and range. Operating margin is operating profit as a percentage of revenue; net margin is consolidated net profit as a percentage of revenue. Negative margins show losses. Missing inputs remain unavailable. Metric definitions.

Fiscal end	Revenue (USD)	Operating margin (%)	Net margin (%)	Inputs & filing sources
2025-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -62140000; netIncome: -63058000 operatingIncome (2026-03-20) netIncome (2026-03-20)
2024-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -42102000; netIncome: -41519000 operatingIncome (2026-03-20) netIncome (2026-03-20)
2023-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -61098000; netIncome: -59685000 operatingIncome (2025-03-13) netIncome (2025-03-13)
2022-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -59642000; netIncome: -58388000 operatingIncome (2024-03-21) netIncome (2024-03-21)
2021-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -43073000; netIncome: -42853000 operatingIncome (2023-03-29) netIncome (2023-03-29)
2020-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -50710000; netIncome: -49967000 operatingIncome (2022-03-24) netIncome (2022-03-24)
2019-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -57881000; netIncome: -55229000 operatingIncome (2021-03-29) netIncome (2021-03-29)
2018-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -23822000; netIncome: -23185000 operatingIncome (2020-10-23) netIncome (2020-10-23)

Milestone Pharmaceuticals Inc. (MIST) P/E ratio history

The interactive P/E chart contains all 388 stored weekly price points (2019-05-10–2026-10-08); 0 have an eligible basic or diluted ratio. Annual EPS is carried forward from its fiscal end. Use the P/E range bar or any other chart range bar to change all five chart windows.

Fiscal-year-end snapshots

No positive annual EPS with an eligible fiscal-year-end price is available in this snapshot.

Annual P/E = eligible fiscal-year-end close ÷ reported annual EPS. This is retrospective annual P/E, not TTM or forward P/E. Why we use annual data. Missing or non-positive EPS and missing eligible prices produce unavailable ratios.

Explore the P/E chart and optional reference lines · How P/E history is calculated.

Complete annual P/E history (8 fiscal periods)

Full stored fiscal-year-end P/E history, independent of the selected chart window. Ratios in ×; prices in USD.
Fiscal end	Price date	Close	Price basis	Basic P/E	Diluted P/E	EPS filings
2025-12-31	2025-12-26	2.08	Adjusted close	Unavailable	Unavailable	Basic EPS (2026-03-20) Diluted EPS (2026-03-20)
2024-12-31	2024-12-27	2.15	Adjusted close	Unavailable	Unavailable	Basic EPS (2026-03-20) Diluted EPS (2026-03-20)
2023-12-31	2023-12-29	1.67	Adjusted close	Unavailable	Unavailable	Basic EPS (2025-03-13) Diluted EPS (2025-03-13)
2022-12-31	2022-12-30	3.96	Adjusted close	Unavailable	Unavailable	Basic EPS (2024-03-21) Diluted EPS (2024-03-21)
2021-12-31	2021-12-31	6.55	Adjusted close	Unavailable	Unavailable	Basic EPS (2023-03-29) Diluted EPS (2022-03-24)
2020-12-31	2020-12-31	6.70	Adjusted close	Unavailable	Unavailable	Basic EPS (2022-03-24) Diluted EPS (2022-03-24)
2019-12-31	2019-12-27	15.40	Adjusted close	Unavailable	Unavailable	Source unavailable
2018-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Source unavailable

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