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Sionna Therapeutics, Inc. (SION)
Price & fundamentals
Compound Annual Growth Rate(CAGR)
Historical valuation multiples
Ratio observations in the selected window
| Price date | EPS fiscal end | Basic P/E (×) | Diluted P/E (×) | P/S (×) | P/FCF (×) |
|---|
Profit margins
Calculation inputs, filings & unavailable observations
Yield, cash conversion & capital returns
Calculation inputs, filings & unavailable observations
Price & growth-based reference
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YEAR-OVER-YEAR
Annual metric change
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Annual data and sources
Sionna Therapeutics, Inc. (SION) · Nasdaq · USD · Sector unavailable · CIK 0002036042
Annual coverage: 2024-12-31–2025-12-31 (2 periods). Financial snapshot built 2026-10-09.
SION annual financial history
All stored annual observations, independent of the chart window. Per-share amounts in USD. Unavailable values are not zero.
See the calculation and limitations.
| Fiscal year / end | Basic EPS | Diluted EPS | FCF / share | Dividends / share | Fiscal-year dividend yield | Filing sources |
|---|---|---|---|---|---|---|
| 2025 2025-12-31 | -1.88 | -1.88 | -1.67 | Unavailable | Unavailable | Basic EPS (2026-03-02) Diluted EPS (2026-03-02) Operating cash flow (2026-03-02) · Capex (2026-03-02) |
| 2024 2024-12-31 | -15.99 | -15.99 | -13.69 | Unavailable | Unavailable | Basic EPS (2026-03-02) Diluted EPS (2026-03-02) Operating cash flow (2026-03-02) · Capex (2026-03-02) |
Annual per-share context (USD/share)
Complete annual history, independent of chart loading and range. Revenue/share is annual revenue per average diluted share. Debt/share is borrowings per year-end common share, excluding leases. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | Revenue / share | Total debt / share | Inputs & filing sources |
|---|---|---|---|
| 2025-12-31 | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; averageDilutedShares: 39962163; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 44723585 averageDilutedShares (2026-03-02)periodEndShares (2026-03-02) |
| 2024-12-31 | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; averageDilutedShares: 3858859; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 4722763 averageDilutedShares (2026-03-02)periodEndShares (2026-03-02) |
Annual returns and cash generation (%)
Complete annual history, independent of chart loading and range. FCF margin and FCF / net income use matching annual totals. ROCE uses positive exact opening and closing capital-employed bases. Inputs, scopes and unavailable reasons are disclosed below. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | FCF margin (%) | FCF / net income (%) | ROCE (%) | Inputs & filing sources |
|---|---|---|---|---|
| 2025-12-31 | Unavailable | Unavailable | -36.35 | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-66674000,"capex":{"accession":"0001628280-26-012996","end":"2025-12-31","filed":"2026-03-02","form":"10-K","start":"2025-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001628280-26-012996","end":"2025-12-31","filed":"2026-03-02","form":"10-K","start":"2025-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-75268000,"tag":"NetIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"operatingIncome":{"value":-88982000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingAssets":{"value":185752000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingCurrentLiabilities":{"value":10420000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingCapitalEmployed":{"value":175332000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":-163713000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":19097000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingCash":{"value":37788000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingCommonEquity":{"value":-163713000,"inputNames":["openingParentEquity","openingPreferredShares"]},"closingAssets":{"value":325953000,"tag":"Assets","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingCurrentLiabilities":{"value":11712000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingCapitalEmployed":{"value":314241000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":306833000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingTotalEquity":{"value":306833000,"inputNames":["closingParentEquity","closingAssets","closingLiabilities"]},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":19120000,"tag":"Liabilities","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingCash":{"value":58451000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2025-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingCommonEquity":{"value":306833000,"inputNames":["closingParentEquity","closingPreferredShares"]},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-75268000,"tag":"NetIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":244786500,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -36.35086085221203 fcfMargin component 1 (2026-03-02) · fcfMargin component 2 (2026-03-02)cashConversion component 1 (2026-03-02) · cashConversion component 2 (2026-03-02) · cashConversion component 3 (2026-03-02) roce component 1 (2026-03-02) · roce component 2 (2026-03-02) · roce component 3 (2026-03-02) · roce component 4 (2026-03-02) · roce component 5 (2026-03-02) |
| 2024-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-52814000,"capex":{"accession":"0001628280-26-012996","end":"2024-12-31","filed":"2026-03-02","form":"10-K","start":"2024-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001628280-26-012996","end":"2024-12-31","filed":"2026-03-02","form":"10-K","start":"2024-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-61688000,"tag":"NetIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"operatingIncome":{"value":-70556000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingAssets":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCurrentLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCapitalEmployed":{"value":null,"inputNames":["openingAssets","openingCurrentLiabilities"],"reason":"Exact assets/current-liabilities balance missing, conflicting or from different filings at 2023-12-31"},"openingParentEquity":{"value":-114881000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2023-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCash":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2023-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":185752000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingCurrentLiabilities":{"value":10420000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingCapitalEmployed":{"value":175332000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":-163713000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":19097000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingCash":{"value":37788000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"closingCommonEquity":{"value":-163713000,"inputNames":["closingParentEquity","closingPreferredShares"]},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-61688000,"tag":"NetIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-02","accession":"0001628280-26-012996","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":null,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: matching numerator and positive exact opening/closing CapitalEmployed required; ambiguous scopes remain unavailable; unavailable: openingCapitalEmployed; Exact assets/current-liabilities balance missing, conflicting or from different filings at 2023-12-31 fcfMargin component 1 (2026-03-02) · fcfMargin component 2 (2026-03-02)cashConversion component 1 (2026-03-02) · cashConversion component 2 (2026-03-02) · cashConversion component 3 (2026-03-02) roce component 1 (2026-03-02) · roce component 2 (2026-03-02) · roce component 3 (2026-03-02) |
Annual operating facts
Complete annual history, independent of chart loading and range. Operating margin is operating profit as a percentage of revenue; net margin is consolidated net profit as a percentage of revenue. Negative margins show losses. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | Revenue (USD) | Operating margin (%) | Net margin (%) | Inputs & filing sources |
|---|---|---|---|---|
| 2025-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; operatingIncome: -88982000; netIncome: -75268000 operatingIncome (2026-03-02)netIncome (2026-03-02) |
| 2024-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; operatingIncome: -70556000; netIncome: -61688000 operatingIncome (2026-03-02)netIncome (2026-03-02) |
Sionna Therapeutics, Inc. (SION) P/E ratio history
The interactive P/E chart contains all 88 stored weekly price points (2025-02-07–2026-10-08); 0 have an eligible basic or diluted ratio. Annual EPS is carried forward from its fiscal end. Use the P/E range bar or any other chart range bar to change all five chart windows.
Fiscal-year-end snapshots
No positive annual EPS with an eligible fiscal-year-end price is available in this snapshot.
Annual P/E = eligible fiscal-year-end close ÷ reported annual EPS. This is retrospective annual P/E, not TTM or forward P/E. Why we use annual data. Missing or non-positive EPS and missing eligible prices produce unavailable ratios.
Explore the P/E chart and optional reference lines · How P/E history is calculated.
Complete annual P/E history (2 fiscal periods)
| Fiscal end | Price date | Close | Price basis | Basic P/E | Diluted P/E | EPS filings |
|---|---|---|---|---|---|---|
| 2025-12-31 | 2025-12-26 | 43.70 | Adjusted close | Unavailable | Unavailable | Basic EPS (2026-03-02) Diluted EPS (2026-03-02) |
| 2024-12-31 | Unavailable | Unavailable | Unavailable | Unavailable | Unavailable | Basic EPS (2026-03-02) Diluted EPS (2026-03-02) |
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