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SPRUCE BIOSCIENCES, INC. (SPRB)

Historical prices through 2026-10-08Latest fiscal period 2025-12-31

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SPRUCE BIOSCIENCES, INC. (SPRB) · Nasdaq · USD · Sector unavailable · CIK 0001683553

Annual coverage: 2019-12-31–2025-12-31 (7 periods). Financial snapshot built 2026-10-09.

SPRB annual financial history

All stored annual observations, independent of the chart window. Per-share amounts in USD. Unavailable values are not zero.

See the calculation and limitations.

Annual EPS, cash flow, dividends, and fiscal-year dividend yield for SPRUCE BIOSCIENCES, INC.
Fiscal year / end	Basic EPS	Diluted EPS	FCF / share	Dividends / share	Fiscal-year dividend yield	Filing sources
2025 2025-12-31	-50.83	-50.83	Unavailable	Unavailable	Unavailable	Basic EPS (2026-03-09) Diluted EPS (2026-03-09)
2024 2024-12-31	-96.40	-96.40	-101.73	Unavailable	Unavailable	Basic EPS (2026-03-09) Diluted EPS (2026-03-09) Operating cash flow (2026-03-09) · Capex (2025-04-15)
2023 2023-12-31	-1.24	-1.24	-0.86	Unavailable	Unavailable	Basic EPS (2025-04-15) Diluted EPS (2025-04-15) Operating cash flow (2025-04-15) · Capex (2025-04-15)
2022 2022-12-31	-1.96	-1.96	-1.77	Unavailable	Unavailable	Basic EPS (2024-03-18) Diluted EPS (2024-03-18) Operating cash flow (2024-03-18) · Capex (2024-03-18)
2021 2021-12-31	-1.81	-1.81	-1.54	Unavailable	Unavailable	Basic EPS (2023-03-16) Diluted EPS (2023-03-16) Operating cash flow (2023-03-16) · Capex (2023-03-16)
2020 2020-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Operating cash flow (2022-03-14) · Capex (2022-03-14)
2019 2019-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Operating cash flow (2021-03-22) · Capex (2021-03-22)

Annual per-share context (USD/share)

Complete annual history, independent of chart loading and range. Revenue/share is annual revenue per average diluted share. Debt/share is borrowings per year-end common share, excluding leases. Missing inputs remain unavailable. Metric definitions.

Fiscal end	Revenue / share	Total debt / share	Inputs & filing sources
2025-12-31	0.00	Unavailable	Inputs & filings revenue: 0; averageDilutedShares: 766598; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 1372043 revenue (2026-03-09) averageDilutedShares (2026-03-09) periodEndShares (2026-03-09)
2024-12-31	8.93	Unavailable	Inputs & filings revenue: 4911000; averageDilutedShares: 550146; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 563042 revenue (2026-03-09) averageDilutedShares (2026-03-09) periodEndShares (2026-03-09)
2023-12-31	0.26	Unavailable	Inputs & filings revenue: 10089000; averageDilutedShares: 38510220; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 41029832 revenue (2025-04-15) averageDilutedShares (2025-04-15) periodEndShares (2025-04-15)
2022-12-31	0.00	Unavailable	Inputs & filings revenue: 0; averageDilutedShares: 23527116; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 23601004 revenue (2024-03-18) averageDilutedShares (2024-03-18) periodEndShares (2024-03-18)
2021-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: 23361416; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 23491881 averageDilutedShares (2023-03-16) periodEndShares (2023-03-16)
2020-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 23260399 periodEndShares (2022-03-14)
2019-12-31	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 764408 periodEndShares (2021-03-22)

Annual returns and cash generation (%)

Complete annual history, independent of chart loading and range. FCF margin and FCF / net income use matching annual totals. ROCE uses positive exact opening and closing capital-employed bases. Inputs, scopes and unavailable reasons are disclosed below. Missing inputs remain unavailable. Metric definitions.

Fiscal end	FCF margin (%)	FCF / net income (%)	ROCE (%)	Inputs & filing sources
2025-12-31	Unavailable	Unavailable	-100.18	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"revenue":{"value":0,"tag":"Revenues","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"netIncome":{"value":-38966000,"tag":"ProfitLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"operatingIncome":{"value":-36513000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingAssets":{"value":45209000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingCurrentLiabilities":{"value":15246000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingCapitalEmployed":{"value":29963000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":28821000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingTotalEquity":{"value":28821000,"inputNames":["openingParentEquity","openingAssets","openingLiabilities"]},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":16388000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingCash":{"value":38753000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingCommonEquity":{"value":28821000,"inputNames":["openingParentEquity","openingPreferredShares"]},"closingAssets":{"value":53021000,"tag":"Assets","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingCurrentLiabilities":{"value":10086000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingCapitalEmployed":{"value":42935000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":42516000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingTotalEquity":{"value":42516000,"inputNames":["closingParentEquity","closingAssets","closingLiabilities"]},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":10505000,"tag":"Liabilities","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingCash":{"value":48906000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2025-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingCommonEquity":{"value":42516000,"inputNames":["closingParentEquity","closingPreferredShares"]},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-38966000,"tag":"NetIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":36449000,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":35668500,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: Stored FCF total has no matching annual OCF/capex duration; cashConversion: Stored FCF total has no matching annual OCF/capex duration; roce: -100.17558780762161 fcfMargin component 1 (2026-03-09) cashConversion component 1 (2026-03-09) roce component 1 (2026-03-09) · roce component 2 (2026-03-09) · roce component 3 (2026-03-09) · roce component 4 (2026-03-09) · roce component 5 (2026-03-09)
2024-12-31	-1,139.56	Unavailable	-102.61	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-55964000,"capex":{"accession":"0000950170-25-053945","end":"2024-12-31","filed":"2025-04-15","form":"10-K","start":"2024-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001193125-26-097558","end":"2024-12-31","filed":"2026-03-09","form":"10-K","start":"2024-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":4911000,"tag":"Revenues","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"netIncome":{"value":-53036000,"tag":"ProfitLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"operatingIncome":{"value":-56151000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingAssets":{"value":103946000,"tag":"Assets","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"openingCurrentLiabilities":{"value":24465000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"openingCapitalEmployed":{"value":79481000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":76509000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2023-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":27437000,"tag":"Liabilities","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"openingCash":{"value":96339000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2023-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2023-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":45209000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingCurrentLiabilities":{"value":15246000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingCapitalEmployed":{"value":29963000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":28821000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingTotalEquity":{"value":28821000,"inputNames":["closingParentEquity","closingAssets","closingLiabilities"]},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":16388000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingCash":{"value":38753000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"closingCommonEquity":{"value":28821000,"inputNames":["closingParentEquity","closingPreferredShares"]},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-53036000,"tag":"NetIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-09","accession":"0001193125-26-097558","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":54722000,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{"fcfMargin":{"fcfTotal":{"value":-55964000,"ocf":{"tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"capex":{"tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"}},"revenue":{"value":4911000,"tag":"Revenues","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"}}}}; fcfMargin: -1139.5642435349216; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -102.6113811629692 fcfMargin component 1 (2025-04-15) · fcfMargin component 2 (2025-04-15) · fcfMargin component 3 (2025-04-15) cashConversion component 1 (2026-03-09) · cashConversion component 2 (2025-04-15) · cashConversion component 3 (2026-03-09) roce component 1 (2026-03-09) · roce component 2 (2025-04-15) · roce component 3 (2025-04-15) · roce component 4 (2026-03-09) · roce component 5 (2026-03-09)
2023-12-31	-329.88	Unavailable	-68.11	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-33282000,"capex":{"accession":"0000950170-25-053945","end":"2023-12-31","filed":"2025-04-15","form":"10-K","start":"2023-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-25-053945","end":"2023-12-31","filed":"2025-04-15","form":"10-K","start":"2023-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":10089000,"tag":"Revenues","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"netIncome":{"value":-47919000,"tag":"ProfitLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"operatingIncome":{"value":-51993000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"openingAssets":{"value":85648000,"tag":"Assets","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-18","accession":"0000950170-24-032819","form":"10-K"},"openingCurrentLiabilities":{"value":12447000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-18","accession":"0000950170-24-032819","form":"10-K"},"openingCapitalEmployed":{"value":73201000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":68486000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2022-12-31","filed":"2025-04-15","accession":"0000950170-25-053945","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":17162000,"tag":"Liabilities","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-18","accession":"0000950170-24-032819","form":"10-K"},"openingCash":{"value":24487000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-18","accession":"0000950170-24-032819","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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2022-12-31	Unavailable	Unavailable	-49.56	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-41691000,"capex":{"accession":"0000950170-24-032819","end":"2022-12-31","filed":"2024-03-18","form":"10-K","start":"2022-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-24-032819","end":"2022-12-31","filed":"2024-03-18","form":"10-K","start":"2022-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":0,"tag":"Revenues","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-18","accession":"0000950170-24-032819","form":"10-K"},"netIncome":{"value":-46180000,"tag":"ProfitLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-18","accession":"0000950170-24-032819","form":"10-K"},"operatingIncome":{"value":-47283000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-18","accession":"0000950170-24-032819","form":"10-K"},"openingAssets":{"value":126486000,"tag":"Assets","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-16","accession":"0000950170-23-008456","form":"10-K"},"openingCurrentLiabilities":{"value":8871000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-16","accession":"0000950170-23-008456","form":"10-K"},"openingCapitalEmployed":{"value":117615000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":111371000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2021-12-31","filed":"2024-03-18","accession":"0000950170-24-032819","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":15115000,"tag":"Liabilities","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-16","accession":"0000950170-23-008456","form":"10-K"},"openingCash":{"value":42748000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-16","accession":"0000950170-23-008456","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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2021-12-31	Unavailable	Unavailable	-31.08	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-35970000,"capex":{"accession":"0000950170-23-008456","end":"2021-12-31","filed":"2023-03-16","form":"10-K","start":"2021-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-23-008456","end":"2021-12-31","filed":"2023-03-16","form":"10-K","start":"2021-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-42292000,"tag":"ProfitLoss","unit":"USD","start":"2021-01-01","end":"2021-12-31","filed":"2023-03-16","accession":"0000950170-23-008456","form":"10-K"},"operatingIncome":{"value":-42066000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2021-01-01","end":"2021-12-31","filed":"2023-03-16","accession":"0000950170-23-008456","form":"10-K"},"openingAssets":{"value":162883000,"tag":"Assets","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"openingCurrentLiabilities":{"value":9763000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"openingCapitalEmployed":{"value":153120000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":149427000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2020-12-31","filed":"2023-03-16","accession":"0000950170-23-008456","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":13456000,"tag":"Liabilities","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"openingCash":{"value":157150000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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2020-12-31	Unavailable	Unavailable	-38.32	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-27593000,"capex":{"accession":"0000950170-22-003582","end":"2020-12-31","filed":"2022-03-14","form":"10-K","start":"2020-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-22-003582","end":"2020-12-31","filed":"2022-03-14","form":"10-K","start":"2020-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-29539000,"tag":"ProfitLoss","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"operatingIncome":{"value":-29416000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"openingAssets":{"value":4692000,"tag":"Assets","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"openingCurrentLiabilities":{"value":4303000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"openingCapitalEmployed":{"value":389000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":-30637000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2019-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":7516000,"tag":"Liabilities","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"openingCash":{"value":3924000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2019-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":162883000,"tag":"Assets","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"closingCurrentLiabilities":{"value":9763000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"closingCapitalEmployed":{"value":153120000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":149427000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2020-12-31","filed":"2023-03-16","accession":"0000950170-23-008456","form":"10-K"},"closingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":13456000,"tag":"Liabilities","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"closingCash":{"value":157150000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2020-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-29539000,"tag":"NetIncomeLoss","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":76754500,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -38.32478877459953 fcfMargin component 1 (2022-03-14) · fcfMargin component 2 (2022-03-14) cashConversion component 1 (2022-03-14) · cashConversion component 2 (2022-03-14) · cashConversion component 3 (2022-03-14) roce component 1 (2022-03-14) · roce component 2 (2021-03-22) · roce component 3 (2021-03-22) · roce component 4 (2022-03-14) · roce component 5 (2022-03-14)
2019-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings Calculation inputs: {"original":{"fcfTotal":{"value":-12621000,"capex":{"accession":"0001564590-21-014593","end":"2019-12-31","filed":"2021-03-22","form":"10-K","start":"2019-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001564590-21-014593","end":"2019-12-31","filed":"2021-03-22","form":"10-K","start":"2019-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-13088000,"tag":"ProfitLoss","unit":"USD","start":"2019-01-01","end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"operatingIncome":{"value":-13107000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2019-01-01","end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"openingAssets":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCurrentLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCapitalEmployed":{"value":null,"inputNames":["openingAssets","openingCurrentLiabilities"],"reason":"Exact assets/current-liabilities balance missing, conflicting or from different filings at 2018-12-31"},"openingParentEquity":{"value":-17802000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2018-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCash":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2018-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":4692000,"tag":"Assets","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"closingCurrentLiabilities":{"value":4303000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"closingCapitalEmployed":{"value":389000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":-30637000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2019-12-31","filed":"2022-03-14","accession":"0000950170-22-003582","form":"10-K"},"closingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":7516000,"tag":"Liabilities","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"closingCash":{"value":3924000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2019-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-13088000,"tag":"NetIncomeLoss","unit":"USD","start":"2019-01-01","end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2019-01-01","end":"2019-12-31","filed":"2021-03-22","accession":"0001564590-21-014593","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":null,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: matching numerator and positive exact opening/closing CapitalEmployed required; ambiguous scopes remain unavailable; unavailable: openingCapitalEmployed; Exact assets/current-liabilities balance missing, conflicting or from different filings at 2018-12-31 fcfMargin component 1 (2021-03-22) · fcfMargin component 2 (2021-03-22) cashConversion component 1 (2021-03-22) · cashConversion component 2 (2021-03-22) · cashConversion component 3 (2021-03-22) roce component 1 (2021-03-22) · roce component 2 (2021-03-22) · roce component 3 (2021-03-22)

Annual operating facts

Complete annual history, independent of chart loading and range. Operating margin is operating profit as a percentage of revenue; net margin is consolidated net profit as a percentage of revenue. Negative margins show losses. Missing inputs remain unavailable. Metric definitions.

Fiscal end	Revenue (USD)	Operating margin (%)	Net margin (%)	Inputs & filing sources
2025-12-31	0.00	Unavailable	Unavailable	Inputs & filings revenue: 0; operatingIncome: -36513000; netIncome: -38966000 revenue (2026-03-09) operatingIncome (2026-03-09) netIncome (2026-03-09)
2024-12-31	4,911,000.00	-1,143.37	-1,079.94	Inputs & filings revenue: 4911000; operatingIncome: -56151000; netIncome: -53036000 revenue (2026-03-09) operatingIncome (2026-03-09) netIncome (2026-03-09)
2023-12-31	10,089,000.00	-515.34	-474.96	Inputs & filings revenue: 10089000; operatingIncome: -51993000; netIncome: -47919000 revenue (2025-04-15) operatingIncome (2025-04-15) netIncome (2025-04-15)
2022-12-31	0.00	Unavailable	Unavailable	Inputs & filings revenue: 0; operatingIncome: -47283000; netIncome: -46180000 revenue (2024-03-18) operatingIncome (2024-03-18) netIncome (2024-03-18)
2021-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -42066000; netIncome: -42292000 operatingIncome (2023-03-16) netIncome (2023-03-16)
2020-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -29416000; netIncome: -29539000 operatingIncome (2022-03-14) netIncome (2022-03-14)
2019-12-31	Unavailable	Unavailable	Unavailable	Inputs & filings revenue: No unambiguous matching annual USD fact; operatingIncome: -13107000; netIncome: -13088000 operatingIncome (2021-03-22) netIncome (2021-03-22)

SPRUCE BIOSCIENCES, INC. (SPRB) P/E ratio history

The interactive P/E chart contains all 56 stored weekly price points (2025-09-19–2026-10-08); 0 have an eligible basic or diluted ratio. Annual EPS is carried forward from its fiscal end. Use the P/E range bar or any other chart range bar to change all five chart windows.

Fiscal-year-end snapshots

No positive annual EPS with an eligible fiscal-year-end price is available in this snapshot.

Annual P/E = eligible fiscal-year-end close ÷ reported annual EPS. This is retrospective annual P/E, not TTM or forward P/E. Why we use annual data. Missing or non-positive EPS and missing eligible prices produce unavailable ratios.

Explore the P/E chart and optional reference lines · How P/E history is calculated.

Complete annual P/E history (7 fiscal periods)

Full stored fiscal-year-end P/E history, independent of the selected chart window. Ratios in ×; prices in USD.
Fiscal end	Price date	Close	Price basis	Basic P/E	Diluted P/E	EPS filings
2025-12-31	2025-12-26	85.74	Adjusted close	Unavailable	Unavailable	Basic EPS (2026-03-09) Diluted EPS (2026-03-09)
2024-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Basic EPS (2026-03-09) Diluted EPS (2026-03-09)
2023-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Basic EPS (2025-04-15) Diluted EPS (2025-04-15)
2022-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Basic EPS (2024-03-18) Diluted EPS (2024-03-18)
2021-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Basic EPS (2023-03-16) Diluted EPS (2023-03-16)
2020-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Source unavailable
2019-12-31	Unavailable	Unavailable	Unavailable	Unavailable	Unavailable	Source unavailable

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