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Tyra Biosciences, Inc. (TYRA)
Price & fundamentals
Compound Annual Growth Rate(CAGR)
Historical valuation multiples
Ratio observations in the selected window
| Price date | EPS fiscal end | Basic P/E (×) | Diluted P/E (×) | P/S (×) | P/FCF (×) |
|---|
Profit margins
Calculation inputs, filings & unavailable observations
Yield, cash conversion & capital returns
Calculation inputs, filings & unavailable observations
Price & growth-based reference
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YEAR-OVER-YEAR
Annual metric change
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Annual data and sources
Tyra Biosciences, Inc. (TYRA) · Nasdaq · USD · Sector unavailable · CIK 0001863127
Annual coverage: 2020-12-31–2025-12-31 (6 periods). Financial snapshot built 2026-10-09.
TYRA annual financial history
All stored annual observations, independent of the chart window. Per-share amounts in USD. Unavailable values are not zero.
See the calculation and limitations.
| Fiscal year / end | Basic EPS | Diluted EPS | FCF / share | Dividends / share | Fiscal-year dividend yield | Filing sources |
|---|---|---|---|---|---|---|
| 2025 2025-12-31 | -2.01 | -2.01 | -1.60 | Unavailable | Unavailable | Basic EPS (2026-03-02) Diluted EPS (2026-03-02) Operating cash flow (2026-03-02) · Capex (2026-03-02) |
| 2024 2024-12-31 | -1.51 | -1.51 | -1.23 | Unavailable | Unavailable | Basic EPS (2026-03-02) Diluted EPS (2026-03-02) Operating cash flow (2026-03-02) · Capex (2026-03-02) |
| 2023 2023-12-31 | -1.62 | -1.62 | -1.19 | Unavailable | Unavailable | Basic EPS (2025-03-27) Diluted EPS (2025-03-27) Operating cash flow (2025-03-27) · Capex (2025-03-27) |
| 2022 2022-12-31 | -1.32 | -1.32 | -1.21 | Unavailable | Unavailable | Basic EPS (2024-03-19) Diluted EPS (2024-03-19) Operating cash flow (2024-03-19) · Capex (2024-03-19) |
| 2021 2021-12-31 | -1.91 | -1.91 | -1.77 | Unavailable | Unavailable | Basic EPS (2023-03-22) Diluted EPS (2023-03-22) Operating cash flow (2023-03-22) · Capex (2023-03-22) |
| 2020 2020-12-31 | Unavailable | Unavailable | Unavailable | Unavailable | Unavailable | Operating cash flow (2022-03-03) · Capex (2022-03-03) |
Annual per-share context (USD/share)
Complete annual history, independent of chart loading and range. Revenue/share is annual revenue per average diluted share. Debt/share is borrowings per year-end common share, excluding leases. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | Revenue / share | Total debt / share | Inputs & filing sources |
|---|---|---|---|
| 2025-12-31 | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; averageDilutedShares: 59602328; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 53706357 averageDilutedShares (2026-03-02)periodEndShares (2026-03-02) |
| 2024-12-31 | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; averageDilutedShares: 57217746; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 50749945 averageDilutedShares (2026-03-02)periodEndShares (2026-03-02) |
| 2023-12-31 | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; averageDilutedShares: 42704876; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 43024634 averageDilutedShares (2025-03-27)periodEndShares (2025-03-27) |
| 2022-12-31 | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; averageDilutedShares: 41883904; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 42353550 averageDilutedShares (2024-03-19)periodEndShares (2024-03-19) |
| 2021-12-31 | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; averageDilutedShares: 13780546; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 41441135 averageDilutedShares (2023-03-22)periodEndShares (2023-03-22) |
| 2020-12-31 | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; averageDilutedShares: No positive shares on the exact annual duration; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 1829377 periodEndShares (2022-03-03) |
Annual returns and cash generation (%)
Complete annual history, independent of chart loading and range. FCF margin and FCF / net income use matching annual totals. ROCE uses positive exact opening and closing capital-employed bases. Inputs, scopes and unavailable reasons are disclosed below. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | FCF margin (%) | FCF / net income (%) | ROCE (%) | Inputs & filing sources |
|---|---|---|---|---|
| 2025-12-31 | Unavailable | Unavailable | -43.28 | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-95283000,"capex":{"accession":"0001193125-26-085490","end":"2025-12-31","filed":"2026-03-02","form":"10-K","start":"2025-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001193125-26-085490","end":"2025-12-31","filed":"2026-03-02","form":"10-K","start":"2025-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-119947000,"tag":"NetIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"operatingIncome":{"value":-132762000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"openingAssets":{"value":363558000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"openingCurrentLiabilities":{"value":14594000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"openingCapitalEmployed":{"value":348964000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":343151000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"openingTotalEquity":{"value":343151000,"inputNames":["openingParentEquity","openingAssets","openingLiabilities"]},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":20407000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"openingCash":{"value":91966000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2025-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2025-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"closingCommonEquity":{"value":259177000,"inputNames":["closingParentEquity","closingPreferredShares"]},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-119947000,"tag":"NetIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":306739500,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":301164000,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -43.28167712342232 fcfMargin component 1 (2026-03-02) · fcfMargin component 2 (2026-03-02)cashConversion component 1 (2026-03-02) · cashConversion component 2 (2026-03-02) · cashConversion component 3 (2026-03-02) roce component 1 (2026-03-02) · roce component 2 (2026-03-02) · roce component 3 (2026-03-02) · roce component 4 (2026-03-02) · roce component 5 (2026-03-02) |
| 2024-12-31 | Unavailable | Unavailable | -37.24 | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-70438000,"capex":{"accession":"0001193125-26-085490","end":"2024-12-31","filed":"2026-03-02","form":"10-K","start":"2024-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001193125-26-085490","end":"2024-12-31","filed":"2026-03-02","form":"10-K","start":"2024-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-86481000,"tag":"NetIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"operatingIncome":{"value":-104177000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"openingAssets":{"value":225857000,"tag":"Assets","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-27","accession":"0000950170-25-046124","form":"10-K"},"openingCurrentLiabilities":{"value":15333000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-27","accession":"0000950170-25-046124","form":"10-K"},"openingCapitalEmployed":{"value":210524000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":204262000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2023-12-31","filed":"2026-03-02","accession":"0001193125-26-085490","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":21595000,"tag":"Liabilities","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-27","accession":"0000950170-25-046124","form":"10-K"},"openingCash":{"value":58006000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-27","accession":"0000950170-25-046124","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -37.24011953786319 fcfMargin component 1 (2026-03-02) · fcfMargin component 2 (2026-03-02)cashConversion component 1 (2026-03-02) · cashConversion component 2 (2026-03-02) · cashConversion component 3 (2026-03-02) roce component 1 (2026-03-02) · roce component 2 (2025-03-27) · roce component 3 (2025-03-27) · roce component 4 (2026-03-02) · roce component 5 (2026-03-02) |
| 2023-12-31 | Unavailable | Unavailable | -33.95 | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-50909000,"capex":{"accession":"0000950170-25-046124","end":"2023-12-31","filed":"2025-03-27","form":"10-K","start":"2023-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-25-046124","end":"2023-12-31","filed":"2025-03-27","form":"10-K","start":"2023-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-69134000,"tag":"NetIncomeLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-27","accession":"0000950170-25-046124","form":"10-K"},"operatingIncome":{"value":-79945000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-27","accession":"0000950170-25-046124","form":"10-K"},"openingAssets":{"value":266181000,"tag":"Assets","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"openingCurrentLiabilities":{"value":5701000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"openingCapitalEmployed":{"value":260480000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":257829000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2022-12-31","filed":"2025-03-27","accession":"0000950170-25-046124","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":8352000,"tag":"Liabilities","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"openingCash":{"value":251213000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; 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fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -33.94663314961232 fcfMargin component 1 (2025-03-27) · fcfMargin component 2 (2025-03-27)cashConversion component 1 (2025-03-27) · cashConversion component 2 (2025-03-27) · cashConversion component 3 (2025-03-27) roce component 1 (2025-03-27) · roce component 2 (2024-03-19) · roce component 3 (2024-03-19) · roce component 4 (2025-03-27) · roce component 5 (2025-03-27) |
| 2022-12-31 | Unavailable | Unavailable | -20.91 | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-50844000,"capex":{"accession":"0000950170-24-033461","end":"2022-12-31","filed":"2024-03-19","form":"10-K","start":"2022-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-24-033461","end":"2022-12-31","filed":"2024-03-19","form":"10-K","start":"2022-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-55325000,"tag":"NetIncomeLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"operatingIncome":{"value":-58927000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"openingAssets":{"value":306701000,"tag":"Assets","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"openingCurrentLiabilities":{"value":3616000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"openingCapitalEmployed":{"value":303085000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":301737000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2021-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":4964000,"tag":"Liabilities","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"openingCash":{"value":302182000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2021-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":266181000,"tag":"Assets","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"closingCurrentLiabilities":{"value":5701000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"closingCapitalEmployed":{"value":260480000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":257829000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2022-12-31","filed":"2025-03-27","accession":"0000950170-25-046124","form":"10-K"},"closingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":8352000,"tag":"Liabilities","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"closingCash":{"value":251213000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2022-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-55325000,"tag":"NetIncomeLoss","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":2000,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2022-01-01","end":"2022-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":281782500,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -20.91222840311233 fcfMargin component 1 (2024-03-19) · fcfMargin component 2 (2024-03-19)cashConversion component 1 (2024-03-19) · cashConversion component 2 (2024-03-19) · cashConversion component 3 (2024-03-19) roce component 1 (2024-03-19) · roce component 2 (2023-03-22) · roce component 3 (2023-03-22) · roce component 4 (2024-03-19) · roce component 5 (2024-03-19) |
| 2021-12-31 | Unavailable | Unavailable | -16.57 | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-24406000,"capex":{"accession":"0000950170-23-009181","end":"2021-12-31","filed":"2023-03-22","form":"10-K","start":"2021-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-23-009181","end":"2021-12-31","filed":"2023-03-22","form":"10-K","start":"2021-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-26294000,"tag":"NetIncomeLoss","unit":"USD","start":"2021-01-01","end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"operatingIncome":{"value":-26288000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2021-01-01","end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"openingAssets":{"value":16011000,"tag":"Assets","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"openingCurrentLiabilities":{"value":1858000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"openingCapitalEmployed":{"value":14153000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":-13638000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2020-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":1998000,"tag":"Liabilities","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"openingCash":{"value":15224000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2020-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":306701000,"tag":"Assets","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"closingCurrentLiabilities":{"value":3616000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"closingCapitalEmployed":{"value":303085000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":301737000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2021-12-31","filed":"2024-03-19","accession":"0000950170-24-033461","form":"10-K"},"closingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":4964000,"tag":"Liabilities","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"closingCash":{"value":302182000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2021-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-26294000,"tag":"NetIncomeLoss","unit":"USD","start":"2021-01-01","end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":1000,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2021-01-01","end":"2021-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":158619000,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -16.573046104186762 fcfMargin component 1 (2023-03-22) · fcfMargin component 2 (2023-03-22)cashConversion component 1 (2023-03-22) · cashConversion component 2 (2023-03-22) · cashConversion component 3 (2023-03-22) roce component 1 (2023-03-22) · roce component 2 (2022-03-03) · roce component 3 (2022-03-03) · roce component 4 (2023-03-22) · roce component 5 (2023-03-22) |
| 2020-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-8075000,"capex":{"accession":"0000950170-22-002814","end":"2020-12-31","filed":"2022-03-03","form":"10-K","start":"2020-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-22-002814","end":"2020-12-31","filed":"2022-03-03","form":"10-K","start":"2020-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"netIncome":{"value":-9336000,"tag":"NetIncomeLoss","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"operatingIncome":{"value":-9297000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"openingAssets":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCurrentLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCapitalEmployed":{"value":null,"inputNames":["openingAssets","openingCurrentLiabilities"],"reason":"Exact assets/current-liabilities balance missing, conflicting or from different filings at 2019-12-31"},"openingParentEquity":{"value":-4741000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2019-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCash":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2019-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":16011000,"tag":"Assets","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"closingCurrentLiabilities":{"value":1858000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"closingCapitalEmployed":{"value":14153000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":-13638000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2020-12-31","filed":"2023-03-22","accession":"0000950170-23-009181","form":"10-K"},"closingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":1998000,"tag":"Liabilities","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"closingCash":{"value":15224000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2020-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"parentNetIncome":{"value":-9336000,"tag":"NetIncomeLoss","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"preferredDividends":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"incomeTaxExpense":{"value":1000,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2020-01-01","end":"2020-12-31","filed":"2022-03-03","accession":"0000950170-22-002814","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":null,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: No unambiguous matching annual USD fact; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: matching numerator and positive exact opening/closing CapitalEmployed required; ambiguous scopes remain unavailable; unavailable: openingCapitalEmployed; Exact assets/current-liabilities balance missing, conflicting or from different filings at 2019-12-31 fcfMargin component 1 (2022-03-03) · fcfMargin component 2 (2022-03-03)cashConversion component 1 (2022-03-03) · cashConversion component 2 (2022-03-03) · cashConversion component 3 (2022-03-03) roce component 1 (2022-03-03) · roce component 2 (2022-03-03) · roce component 3 (2022-03-03) |
Annual operating facts
Complete annual history, independent of chart loading and range. Operating margin is operating profit as a percentage of revenue; net margin is consolidated net profit as a percentage of revenue. Negative margins show losses. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | Revenue (USD) | Operating margin (%) | Net margin (%) | Inputs & filing sources |
|---|---|---|---|---|
| 2025-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; operatingIncome: -132762000; netIncome: -119947000 operatingIncome (2026-03-02)netIncome (2026-03-02) |
| 2024-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; operatingIncome: -104177000; netIncome: -86481000 operatingIncome (2026-03-02)netIncome (2026-03-02) |
| 2023-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; operatingIncome: -79945000; netIncome: -69134000 operatingIncome (2025-03-27)netIncome (2025-03-27) |
| 2022-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; operatingIncome: -58927000; netIncome: -55325000 operatingIncome (2024-03-19)netIncome (2024-03-19) |
| 2021-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; operatingIncome: -26288000; netIncome: -26294000 operatingIncome (2023-03-22)netIncome (2023-03-22) |
| 2020-12-31 | Unavailable | Unavailable | Unavailable | Inputs & filingsrevenue: No unambiguous matching annual USD fact; operatingIncome: -9297000; netIncome: -9336000 operatingIncome (2022-03-03)netIncome (2022-03-03) |
Tyra Biosciences, Inc. (TYRA) P/E ratio history
The interactive P/E chart contains all 265 stored weekly price points (2021-09-17–2026-10-08); 0 have an eligible basic or diluted ratio. Annual EPS is carried forward from its fiscal end. Use the P/E range bar or any other chart range bar to change all five chart windows.
Fiscal-year-end snapshots
No positive annual EPS with an eligible fiscal-year-end price is available in this snapshot.
Annual P/E = eligible fiscal-year-end close ÷ reported annual EPS. This is retrospective annual P/E, not TTM or forward P/E. Why we use annual data. Missing or non-positive EPS and missing eligible prices produce unavailable ratios.
Explore the P/E chart and optional reference lines · How P/E history is calculated.
Complete annual P/E history (6 fiscal periods)
| Fiscal end | Price date | Close | Price basis | Basic P/E | Diluted P/E | EPS filings |
|---|---|---|---|---|---|---|
| 2025-12-31 | 2025-12-26 | 25.96 | Adjusted close | Unavailable | Unavailable | Basic EPS (2026-03-02) Diluted EPS (2026-03-02) |
| 2024-12-31 | 2024-12-27 | 14.07 | Adjusted close | Unavailable | Unavailable | Basic EPS (2026-03-02) Diluted EPS (2026-03-02) |
| 2023-12-31 | 2023-12-29 | 13.85 | Adjusted close | Unavailable | Unavailable | Basic EPS (2025-03-27) Diluted EPS (2025-03-27) |
| 2022-12-31 | 2022-12-30 | 7.60 | Adjusted close | Unavailable | Unavailable | Basic EPS (2024-03-19) Diluted EPS (2024-03-19) |
| 2021-12-31 | 2021-12-31 | 14.07 | Adjusted close | Unavailable | Unavailable | Basic EPS (2023-03-22) Diluted EPS (2023-03-22) |
| 2020-12-31 | Unavailable | Unavailable | Unavailable | Unavailable | Unavailable | Source unavailable |
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