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Upstream Bio, Inc. (UPB)
Price & fundamentals
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| Price date | EPS fiscal end | Basic P/E (×) | Diluted P/E (×) | P/S (×) | P/FCF (×) |
|---|
Profit margins
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Yield, cash conversion & capital returns
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Upstream Bio, Inc. (UPB) · Nasdaq · USD · Sector unavailable · CIK 0002022626
Annual coverage: 2023-12-31–2025-12-31 (3 periods). Financial snapshot built 2026-10-09.
UPB annual financial history
All stored annual observations, independent of the chart window. Per-share amounts in USD. Unavailable values are not zero.
See the calculation and limitations.
| Fiscal year / end | Basic EPS | Diluted EPS | FCF / share | Dividends / share | Fiscal-year dividend yield | Filing sources |
|---|---|---|---|---|---|---|
| 2025 2025-12-31 | -2.66 | -2.66 | -2.48 | Unavailable | Unavailable | Basic EPS (2026-03-26) Diluted EPS (2026-03-26) Operating cash flow (2026-03-26) · Capex (2026-03-26) |
| 2024 2024-12-31 | -5.58 | -5.58 | -4.36 | Unavailable | Unavailable | Basic EPS (2026-03-26) Diluted EPS (2026-03-26) Operating cash flow (2026-03-26) · Capex (2026-03-26) |
| 2023 2023-12-31 | -12.95 | -12.95 | -12.89 | Unavailable | Unavailable | Basic EPS (2025-03-12) Diluted EPS (2025-03-12) Operating cash flow (2025-03-12) · Capex (2025-03-12) |
Annual per-share context (USD/share)
Complete annual history, independent of chart loading and range. Revenue/share is annual revenue per average diluted share. Debt/share is borrowings per year-end common share, excluding leases. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | Revenue / share | Total debt / share | Inputs & filing sources |
|---|---|---|---|
| 2025-12-31 | 0.05 | Unavailable | Inputs & filingsrevenue: 2854000; averageDilutedShares: 53852752; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 54237750 revenue (2026-03-26)averageDilutedShares (2026-03-26) periodEndShares (2026-03-26) |
| 2024-12-31 | 0.17 | Unavailable | Inputs & filingsrevenue: 2370000; averageDilutedShares: 13682326; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 53603398 revenue (2026-03-26)averageDilutedShares (2026-03-26) periodEndShares (2026-03-26) |
| 2023-12-31 | 0.81 | Unavailable | Inputs & filingsrevenue: 2380000; averageDilutedShares: 2953756; totalDebt: No supported complete debt aggregate or non-overlapping borrowing components; leases excluded; periodEndShares: 2992479 revenue (2025-03-12)averageDilutedShares (2025-03-12) periodEndShares (2025-03-12) |
Annual returns and cash generation (%)
Complete annual history, independent of chart loading and range. FCF margin and FCF / net income use matching annual totals. ROCE uses positive exact opening and closing capital-employed bases. Inputs, scopes and unavailable reasons are disclosed below. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | FCF margin (%) | FCF / net income (%) | ROCE (%) | Inputs & filing sources |
|---|---|---|---|---|
| 2025-12-31 | -4,675.54 | Unavailable | -39.53 | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-133440000,"capex":{"accession":"0001193125-26-126188","end":"2025-12-31","filed":"2026-03-26","form":"10-K","start":"2025-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001193125-26-126188","end":"2025-12-31","filed":"2026-03-26","form":"10-K","start":"2025-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":2854000,"tag":"RevenueFromContractWithCustomerExcludingAssessedTax","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"netIncome":{"value":-143443000,"tag":"ProfitLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"operatingIncome":{"value":-160361000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingAssets":{"value":481719000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingCurrentLiabilities":{"value":10737000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingCapitalEmployed":{"value":470982000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":469852000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingTotalEquity":{"value":469852000,"inputNames":["openingParentEquity","openingAssets","openingLiabilities"]},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":11867000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingCash":{"value":325892000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingCommonEquity":{"value":469852000,"inputNames":["openingParentEquity","openingPreferredShares"]},"closingAssets":{"value":353772000,"tag":"Assets","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingCurrentLiabilities":{"value":13452000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingCapitalEmployed":{"value":340320000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":339771000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingTotalEquity":{"value":339771000,"inputNames":["closingParentEquity","closingAssets","closingLiabilities"]},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":14001000,"tag":"Liabilities","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingCash":{"value":101578000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2025-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingCommonEquity":{"value":339771000,"inputNames":["closingParentEquity","closingPreferredShares"]},"commonNetIncome":{"value":-143443000,"tag":"NetIncomeLossAvailableToCommonStockholdersBasic","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2025-01-01","end":"2025-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":405651000,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":404811500,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: -4675.543097407148; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -39.53176499010233 fcfMargin component 1 (2026-03-26) · fcfMargin component 2 (2026-03-26) · fcfMargin component 3 (2026-03-26)cashConversion component 1 (2026-03-26) · cashConversion component 2 (2026-03-26) · cashConversion component 3 (2026-03-26) roce component 1 (2026-03-26) · roce component 2 (2026-03-26) · roce component 3 (2026-03-26) · roce component 4 (2026-03-26) · roce component 5 (2026-03-26) |
| 2024-12-31 | -2,518.27 | Unavailable | -26.74 | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-59683000,"capex":{"accession":"0001193125-26-126188","end":"2024-12-31","filed":"2026-03-26","form":"10-K","start":"2024-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0001193125-26-126188","end":"2024-12-31","filed":"2026-03-26","form":"10-K","start":"2024-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":2370000,"tag":"RevenueFromContractWithCustomerExcludingAssessedTax","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"netIncome":{"value":-62806000,"tag":"ProfitLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"operatingIncome":{"value":-77764000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingAssets":{"value":117198000,"tag":"Assets","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"openingCurrentLiabilities":{"value":6515000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"openingCapitalEmployed":{"value":110683000,"inputNames":["openingAssets","openingCurrentLiabilities"]},"openingParentEquity":{"value":-123126000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2023-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":9389000,"tag":"Liabilities","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"openingCash":{"value":25833000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2023-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":481719000,"tag":"Assets","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingCurrentLiabilities":{"value":10737000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingCapitalEmployed":{"value":470982000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":469852000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingTotalEquity":{"value":469852000,"inputNames":["closingParentEquity","closingAssets","closingLiabilities"]},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":11867000,"tag":"Liabilities","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingCash":{"value":325892000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2024-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingCommonEquity":{"value":469852000,"inputNames":["closingParentEquity","closingPreferredShares"]},"commonNetIncome":{"value":-76395000,"tag":"NetIncomeLossAvailableToCommonStockholdersBasic","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2024-01-01","end":"2024-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":290832500,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: -2518.270042194093; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: -26.73841472325136 fcfMargin component 1 (2026-03-26) · fcfMargin component 2 (2026-03-26) · fcfMargin component 3 (2026-03-26)cashConversion component 1 (2026-03-26) · cashConversion component 2 (2026-03-26) · cashConversion component 3 (2026-03-26) roce component 1 (2026-03-26) · roce component 2 (2025-03-12) · roce component 3 (2025-03-12) · roce component 4 (2026-03-26) · roce component 5 (2026-03-26) |
| 2023-12-31 | -1,599.58 | Unavailable | Unavailable | Inputs & filingsCalculation inputs: {"original":{"fcfTotal":{"value":-38070000,"capex":{"accession":"0000950170-25-037621","end":"2023-12-31","filed":"2025-03-12","form":"10-K","start":"2023-01-01","tag":"PaymentsToAcquirePropertyPlantAndEquipment","unit":"USD"},"ocf":{"accession":"0000950170-25-037621","end":"2023-12-31","filed":"2025-03-12","form":"10-K","start":"2023-01-01","tag":"NetCashProvidedByUsedInOperatingActivities","unit":"USD"}},"revenue":{"value":2380000,"tag":"RevenueFromContractWithCustomerExcludingAssessedTax","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"netIncome":{"value":-20537000,"tag":"ProfitLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"operatingIncome":{"value":-40114000,"tag":"OperatingIncomeLoss","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"openingAssets":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCurrentLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCapitalEmployed":{"value":null,"inputNames":["openingAssets","openingCurrentLiabilities"],"reason":"Exact assets/current-liabilities balance missing, conflicting or from different filings at 2022-12-31"},"openingParentEquity":{"value":-106155000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2022-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"openingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingLiabilities":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCash":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"openingInvestedCapital":{"value":null,"inputNames":["openingBorrowings","openingTotalEquity","openingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2022-12-31"},"openingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingPreferredShares":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"openingCommonEquity":{"value":null,"inputNames":["openingParentEquity","openingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"closingAssets":{"value":117198000,"tag":"Assets","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"closingCurrentLiabilities":{"value":6515000,"tag":"LiabilitiesCurrent","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"closingCapitalEmployed":{"value":110683000,"inputNames":["closingAssets","closingCurrentLiabilities"]},"closingParentEquity":{"value":-123126000,"tag":"StockholdersEquity","unit":"USD","start":null,"end":"2023-12-31","filed":"2026-03-26","accession":"0001193125-26-126188","form":"10-K"},"closingTotalEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingNoncontrollingEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingLiabilities":{"value":9389000,"tag":"Liabilities","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"closingCash":{"value":25833000,"tag":"CashAndCashEquivalentsAtCarryingValue","unit":"USD","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"closingBorrowings":{"value":null,"reason":"No supported complete debt aggregate or non-overlapping borrowing components; leases excluded"},"closingInvestedCapital":{"value":null,"inputNames":["closingBorrowings","closingTotalEquity","closingCash"],"reason":"Exact complete borrowings, consolidated equity and cash missing, ambiguous or from different filings at 2023-12-31"},"closingPreferredEquity":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"closingPreferredShares":{"value":0,"tag":"PreferredStockSharesOutstanding","unit":"shares","start":null,"end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"closingCommonEquity":{"value":null,"inputNames":["closingParentEquity","closingPreferredShares"],"reason":"Common equity scope requires explicit preferred carrying value or zero preferred shares; absence is not zero"},"commonNetIncome":{"value":-38255000,"tag":"NetIncomeLossAvailableToCommonStockholdersBasic","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"incomeTaxExpense":{"value":0,"tag":"IncomeTaxExpenseBenefit","unit":"USD","start":"2023-01-01","end":"2023-12-31","filed":"2025-03-12","accession":"0000950170-25-037621","form":"10-K"},"pretaxIncome":{"value":null,"reason":"Missing or conflicting matching SEC fact","conflict":false},"effectiveTaxRate":{"value":null,"inputNames":["incomeTaxExpense","pretaxIncome"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"nopat":{"value":null,"inputNames":["operatingIncome","effectiveTaxRate"],"reason":"Matching annual income-tax expense or supported pretax income unavailable"},"averageInvestedCapital":{"value":null,"inputNames":["openingInvestedCapital","closingInvestedCapital"]},"averageCapitalEmployed":{"value":null,"inputNames":["openingCapitalEmployed","closingCapitalEmployed"]},"averageCommonEquity":{"value":null,"inputNames":["openingCommonEquity","closingCommonEquity"]}},"recovered":{}}; fcfMargin: -1599.579831932773; cashConversion: Positive net income required; zero or negative denominator is unavailable; roce: matching numerator and positive exact opening/closing CapitalEmployed required; ambiguous scopes remain unavailable; unavailable: openingCapitalEmployed; Exact assets/current-liabilities balance missing, conflicting or from different filings at 2022-12-31 fcfMargin component 1 (2025-03-12) · fcfMargin component 2 (2025-03-12) · fcfMargin component 3 (2025-03-12)cashConversion component 1 (2025-03-12) · cashConversion component 2 (2025-03-12) · cashConversion component 3 (2025-03-12) roce component 1 (2025-03-12) · roce component 2 (2025-03-12) · roce component 3 (2025-03-12) |
Annual operating facts
Complete annual history, independent of chart loading and range. Operating margin is operating profit as a percentage of revenue; net margin is consolidated net profit as a percentage of revenue. Negative margins show losses. Missing inputs remain unavailable. Metric definitions.
| Fiscal end | Revenue (USD) | Operating margin (%) | Net margin (%) | Inputs & filing sources |
|---|---|---|---|---|
| 2025-12-31 | 2,854,000.00 | -5,618.82 | -5,026.03 | Inputs & filingsrevenue: 2854000; operatingIncome: -160361000; netIncome: -143443000 revenue (2026-03-26)operatingIncome (2026-03-26) netIncome (2026-03-26) |
| 2024-12-31 | 2,370,000.00 | -3,281.18 | -2,650.04 | Inputs & filingsrevenue: 2370000; operatingIncome: -77764000; netIncome: -62806000 revenue (2026-03-26)operatingIncome (2026-03-26) netIncome (2026-03-26) |
| 2023-12-31 | 2,380,000.00 | -1,685.46 | -862.90 | Inputs & filingsrevenue: 2380000; operatingIncome: -40114000; netIncome: -20537000 revenue (2025-03-12)operatingIncome (2025-03-12) netIncome (2025-03-12) |
Upstream Bio, Inc. (UPB) P/E ratio history
The interactive P/E chart contains all 105 stored weekly price points (2024-10-11–2026-10-08); 0 have an eligible basic or diluted ratio. Annual EPS is carried forward from its fiscal end. Use the P/E range bar or any other chart range bar to change all five chart windows.
Fiscal-year-end snapshots
No positive annual EPS with an eligible fiscal-year-end price is available in this snapshot.
Annual P/E = eligible fiscal-year-end close ÷ reported annual EPS. This is retrospective annual P/E, not TTM or forward P/E. Why we use annual data. Missing or non-positive EPS and missing eligible prices produce unavailable ratios.
Explore the P/E chart and optional reference lines · How P/E history is calculated.
Complete annual P/E history (3 fiscal periods)
| Fiscal end | Price date | Close | Price basis | Basic P/E | Diluted P/E | EPS filings |
|---|---|---|---|---|---|---|
| 2025-12-31 | 2025-12-26 | 29.48 | Adjusted close | Unavailable | Unavailable | Basic EPS (2026-03-26) Diluted EPS (2026-03-26) |
| 2024-12-31 | 2024-12-27 | 19.19 | Adjusted close | Unavailable | Unavailable | Basic EPS (2026-03-26) Diluted EPS (2026-03-26) |
| 2023-12-31 | Unavailable | Unavailable | Unavailable | Unavailable | Unavailable | Basic EPS (2025-03-12) Diluted EPS (2025-03-12) |
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